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  Indian J Med Microbiol
 

Figure 1: Main cellular pathways and implication of their inhibition on immune function. Grb2: Growth factor receptor-bound protein 2, SOS: Son of Sevenless, GTP: Guanosine triphosphate, MAPK: Mitogen-activated protein kinase, PD-L1: Programmed death-ligand 1, PI3K: Phosphoinositide 3-kinase, PIP2: Phosphatidylinositol 4,5-bisphosphate, PIP3: Phosphatidylinositol 3,4,5-trisphosphate, PTEN: Phosphatase and tensin homolog, TSC: tuberous sclerosis complex, AKT: Protein kinase B (PKB), mTOR: Mammalian target of rapamycin, PKC: Protein kinase C, NF-kb: Nuclear Factor kappa-light-chain-enhancer of activated B-cells, APC: Adenomatous polyposis coli.

Figure 1: Main cellular pathways and implication of their inhibition on immune function. Grb2: Growth factor receptor-bound protein 2, SOS: Son of Sevenless, GTP: Guanosine triphosphate, MAPK: Mitogen-activated protein kinase, PD-L1: Programmed death-ligand 1, PI3K: Phosphoinositide 3-kinase, PIP2: Phosphatidylinositol 4,5-bisphosphate, PIP3: Phosphatidylinositol 3,4,5-trisphosphate, PTEN: Phosphatase and tensin homolog, TSC: tuberous sclerosis complex, AKT: Protein kinase B (PKB), mTOR: Mammalian target of rapamycin, PKC: Protein kinase C, NF-kb: Nuclear Factor kappa-light-chain-enhancer of activated B-cells, APC: Adenomatous polyposis coli.