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  Indian J Med Microbiol
 

Figure 1: Pathway for personalized immunotherapy. Baseline assessment of a cancer patient includes profiling of the tumor for driver mutations, mutational load, and gene expression profiles; the tumor microenvironment including programmed death ligand 1 expression and analysis of infiltrating immune populations; and host immune responses and the microbiome. Longitudinal evaluation of fresh serial samples – tumor (brown), blood (red), and microbiome (purple) during treatment (pretreatment, early-on-treatment, response, and progression time points) may unveil potential predictive response biomarkers, resistance mechanisms, and further therapeutic strategies.

Figure 1: Pathway for personalized immunotherapy. Baseline assessment of a cancer patient includes profiling of the tumor for driver mutations, mutational load, and gene expression profiles; the tumor microenvironment including programmed death ligand 1 expression and analysis of infiltrating immune populations; and host immune responses and the microbiome. Longitudinal evaluation of fresh serial samples – tumor (brown), blood (red), and microbiome (purple) during treatment (pretreatment, early-on-treatment, response, and progression time points) may unveil potential predictive response biomarkers, resistance mechanisms, and further therapeutic strategies.