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MET receptor amplification drives resistance to Anti-EGFR therapies


1 Department of Drug Development (DITEP), Gustave Roussy Cancer Campus, Villejuif, France
2 Department of Medical Biology and Pathology, Translational Research Laboratory and Biobank, Gustave Roussy Cancer Campus, Villejuif, France
3 Department of Radiology, Gustave Roussy Cancer Campus, Villejuif, France
4 Department of Drug Development (DITEP), Gustave Roussy Cancer Campus; Department of Medical Biology and Pathology, Translational Research Laboratory and Biobank, Gustave Roussy Cancer Campus, Villejuif, France

Correspondence Address:
Antoine Hollebecque,
Gustave Roussy, 114 Rue Edouard Vaillant, 94805 Villejuif Cedex
France
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/JIPO.JIPO_7_19

Mesenchymal–epithelial transition factor (MET) amplification has been suggested either as a de novo or acquired mechanism of resistance to anti-epidermal growth factor receptor (anti-EGFR) therapy. However, even if MET amplification has been widely described in the preclinical setting, only a few clinical data have confirmed the role of MET in the resistance to anti-EGFR treatment. A 60-year-old man presenting cholangiocarcinoma with EGFR amplification had a tumor response to anti-EGFR therapy. A new on-purpose tumor biopsy performed during tumor progression confirmed the known EGFR amplification as well as a new MET amplification. This clinical observation highlights the role of MET amplification as a mechanism of resistance to EGFR inhibitors.


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    -  Romano PM
    -  Castanon E
    -  Hollebecque A
    -  Lacroix L
    -  Auger N
    -  Angevin E
    -  Tselikas L
    -  Ammari S
    -  Soria JC
    -  Massard C
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