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REVIEW ARTICLE
Year : 2020  |  Volume : 3  |  Issue : 1  |  Page : 16-22

Bromodomain and extra-terminal (BET) domain protein inhibitors for solid tumor cancers


Sarah Cannon Research Institute at HealthONE, Denver, CO, USA

Correspondence Address:
Martin V Nguyen
Sarah Cannon Research Institute at HealthONE, Denver, CO
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/JIPO.JIPO_2_20

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The bromodomain and extraterminal (BET) domain protein family is involved in the process of transcription of genetic information. The BET protein family includes BRD2, BRD3, BRD4, and bromodomain testis-specific protein. BET protein alterations are associated with some solid tumor cancers, including nuclear protein in testis midline carcinoma. BET protein has a role in carcinogenesis and in the regulation of the cell cycle. A number of BET inhibitors have entered clinical trials. This review discusses the results of BET inhibitor clinical trials in solid tumor cancers.


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