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Year : 2018  |  Volume : 1  |  Issue : 2  |  Page : 82-84

Pyoderma gangrenosum following initiation of immune checkpoint inhibitor therapy

1 Department of Dermatology, University of Texas McGovern Medical School, Houston, Texas, USA
2 Department of Dermatology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Correspondence Address:
Dr. Anisha B Patel
1515 Holcombe Blvd, Fct 11.5000, Unit 1452, Houston, Texas 77030-4009
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/JIPO.JIPO_11_18

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Pyoderma gangrenosum (PG) is an ulcerating neutrophilic dermatosis that is often associated with the underlying systemic disease. For example, PG is often a common presenting symptom in patients with hematologic malignancies, most commonly myelodysplastic syndrome (MDS). Here, we present the case of a patient who developed PG and a lichenoid drug eruption after the initiation of ipilimumab and nivolumab immune checkpoint inhibitor (ICPI) therapy. Lichenoid drug eruptions are well known to be associated with ICPI therapy, particularly nivolumab. However, only one case of PG has been reported in association with ipilimumab and no cases have ever been reported with nivolumab. Awareness that PG can be associated with ICPI therapy in patients with MDS can allow physicians to be better prepared to help in early recognition and early treatment to prevent the spread of disease.

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